منابع مشابه
EDTA-dependent platelet phagocytosis. A cytochemical, ultrastructural, and functional characterization.
Platelet satellitosis of polymorphonuclear cells is a phenomenon induced or enhanced by the anticoagulant EDTA. In contrast with previously reported studies, the subject in the present case did not demonstrate platelet satellitism but was profoundly pseudothrombocytopenic owing to platelet phagocytosis. Virtually all polymorphonuclear leukocytes and monocytes contained numerous ingested platele...
متن کاملPlatelet Phagocytosis and Aggregation
The addition of latex particles to native (no anticoagulant) or citrated human platelet-rich plasma (PRP), or to a once-washed platelet suspension causes platelet aggregation. This aggregation is associated with phagocytosis of the latex particles by the platelets and appears to be due to release of adenosine diphosphate (ADP) from the platelets. Adenosine and adenosine monophosphate, which are...
متن کاملEDTA-dependent lymphocyte clumping.
A 79-year old man presented with chest pain and fatigue. He was found to have anemia (hemoglobin 8.8 g/dL) and leukocytosis (white blood cell count 244x10/L) with a predominance of lymphocytes (94%). Flow cytometric study and flourescence in situ hybridization analysis of the peripheral blood lymphocytes were consistent with a diagnosis of mantle cell lymphoma. A peripheral smear obtained from ...
متن کاملTemperature-dependent effects of EDTA on the membrane glycoprotein IIb-IIIa complex and platelet aggregability.
In agreement with previous studies, we observed that incubation of washed human platelets with EDTA at 37 degrees C for short periods caused an irreversible loss of their aggregation response to adenosine diphosphate and markedly diminished their capacity to bind fibrinogen. AP-2 is a monoclonal antibody that reacts with a determinant specific to the glycoprotein (GP) IIb-IIIa complex. We now r...
متن کاملEDTA dependent pseudothrombocytopenia caused by antibodies against the cytoadhesive receptor of platelet gpIIB-IIIA.
AIMS To clarify the mechanisms involved in the development of EDTA dependent pseudothrombocytopenia, particularly the platelet receptors. METHODS Platelets were measured in 33 patients with pseudothrombocytopenia, using different anticoagulants to collect blood samples (direct test). The results were compared with the counts obtained by adding patients' serum or immunoglobulins to normal bloo...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2001
ISSN: 0002-9173,1943-7722
DOI: 10.1309/mg6t-yqjq-7c74-re1v